Kirschner-Schwabe, Acute lymphoblastic leukemia

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Gene expression profiling, using Affymetrix U133A arrays, on 60 prospectively collected samples of children with first relapse of acute lymphoblastic leukemia enrolled on the relapse trial ALL-REZ BFM 2002 of the Berlin-Frankfurt-Muenster study group.

Probe level normalization: calibration and variance stabilization (Huber et al. PMID: 12169536). Probe-set summarization: median polish on the normalized data (Irrizary et al. PMID: 12582260)

Gene expression value:  Normalized and summarized probeset expression value on additive arcsinh (log-like) scale


Information about this file
GenomicScape ID GS-DT-47
Species Homo sapiens
Cell types Leukemia
Study types Gene expression by array
Plateform/chip Affymetrix Human Genome U133 A
Normalization Other
Number of samples 60
Grouping factors cell_subpopulations; time_of_relapse; immunophenotype; site_of_relapse; ALL_REZ_BFM_risk_group; minimal_residual_disease_after_2_induction_cycles; genetic_features; sex; frontline_therapy
Continuous factors age_at_relapse_diagnosis_years
peripheral_blast_count_at_relapse_diagnosis_per_microliter
S_and_G2_M_phase_cells_percent
External database Name: GEO | ID: GSE4698 | Link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE4698
Citations Kirschner-Schwabe R, Lottaz C, Tödling J, Rhein P et al. Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia. Clin Cancer Res 2006 Aug 1;12(15):4553-61. PMID: 16899601
Organization Charité - Universitätsmedizin Berlin
Contact Name: Renate Kirschner-Schwabe; Email: R.Kirschner@charite.de; Phone: +4930450566088; Fax: +4930450566946; Laboratory: Molecular Genetics; Department: Pediatric Oncology/Hematology; Institute: Charité - Universitätsmedizin Berlin; Address: Augustenburger Platz 1; City: Berlin; Zip/postal_code: 12167; Country: Germany; Web_link: http://www.charite.de/paedonko
File name code homo-sapiens_leukemia_gene-expression-by-array_affy-hg-u133a_other_GSE4698_GS-DT-47_2015-04-16
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Upload date 04/16/15
Publication date 04/16/15
Date of release or last update 04/16/15
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